Efficacy of Hexetidine, Thymol and Hydrogen Peroxide-Containing Oral Antiseptics in Reducing Sars-Cov-2 Virus in the Oral Cavity: A Pilot Study

Background: Studies have demonstrated the role of sputum as a site severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) transmission. However, there is limited literature on virucidal efficacy oral antiseptics against SARS-CoV-2 virus. This study investigated three oral-antiseptics compared to placebo-control in infected individuals.
 Methodology: A pilot adults with positive results, determined by reverse transcription-polymerase chain reaction (RT-PCR) <7 days. The were: Hexetidine (0.1% w/v); Thymol (0.063% w/v) and H2O2(1.5%) de-mineralized sterile water (Placebo-control). primary outcome measure was proportion negative RT-PCR results at 15-mins, 30-mins, 1-hour, 2-hours 4-hours After Oral Interventions (AOI) placebo-control. Statistical analysis done using STATA 15.0 software p-values <0.05 considered statistically significant.
 Results: Data from total 66 participants that were baseline (0-min) analysed. At 15-mins AOI, highest negativation samples observed Hexedine group, 69.2% PCR cases converting 46.7% group. In addition, H2O2 AOI (62.5% vs 37.5% respectively) other oral-antiseptics. Across all time-points, oral-antiseptic groups no significant difference which converted status (p>0.05).
 Conclusion: findings this suggest who across treatment various time points. Future studies could compare cycle threshold (ct) viral titre values determine quantitative differences.
 Authors
 S Ogun 1, O Erinoso 2, Aina 3, I Ojo Adejumo 4, Adeniran Bowale C Olaniyi B M Adedoyin 5, Mutiu 6, Saka Oshinaike W Arabambi F Shuaib Salmon H Abdur-Razzaq 7, Njokanma Ojini 8, Ogboye Lajide K Wright Osibogun Abayomi 7